For more than fifty years, the American Childhood Cancer Organization (ACCO) has worked diligently to make childhood cancer a national child health priority. During this time, childhood cancer rates have risen, and cancer remains the number one cause of disease-related death among children in the U.S. Despite advances in adult cancer treatments, most children still endure harsh therapies including chemotherapy, radiation, and invasive surgeries, with little change in protocols over the past three decades. These treatments, given during critical developmental stages, lead to lasting effects such as secondary cancers, brain damage, heart disease, learning disabilities, and infertility. As the oldest national nonprofit founded by and for families affected by childhood cancer, ACCO is uniquely positioned to advocate for these children and their families, addressing the urgent need for research and informational support.