Dear friends and family,

Gio, the youngest of our three children, was diagnosed with Creatine Transporter Deficiency (CTD), a rare genetic brain disease. He struggles every day with basic things like speech and communication. Most troubling, he gets hospitalized multiple times throughout the year due to seizures.

A cure would mean a family at peace, better communication, a healthier and happier child, and a hopeful future. We love him so much and want to do whatever we can to raise money for a treatment.

Give today, and 100% of your donations will support creatine deficiency research.

We Are Ready For A Cure

WHY THIS MATTERS

Creatine isn't just for athletes – it's essential for brain development. Children with creatine deficiencies have a genetic deficit that prevents their body from making or using creatine, causing developmental delays, speech difficulties, and seizures.

100 % OF DONATIONS MADE WILL GO DIRECTLY TO RESEARCH

ACD has invested over $7.6 million in research since its inception, with over $5.1 million invested in 2026 alone! Current research initiatives include:

UC Berkeley - 1-year research award to accelerate the development of a novel method to deliver a key enzyme directly into cells to enable creatine production in individuals with GAMT deficiency.
Johns Hopkins University - 2-year research investment to accelerate their work to deliver creatine to the brain, including to neurons, using dendrimer nanoparticles, without the need for a creatine transporter, to help patients with CTD.
Stanford University - 2-year research award to build upon their work developing new ways to deliver creatine directly into cells without relying on the faulty transporter protein that causes CTD.
Ultragenyx - Investment in the clinical development of a therapy for Creatine Transporter Deficiency (CTD) with a total commitment of $4 million as the program progresses.

OUR VISION FOR THE FUTURE

Since 2012, ACD has led the fight against creatine deficiencies. We've already added GAMT to U.S. federal screening guidelines and are seeing adoption grow worldwide. With CTD, we're working toward the same milestone - and ultimately, a cure. Our vision is that one day all creatine deficiencies will be identified and treated within seven days of birth, and those already living with CCDS will receive treatments to achieve their maximum potential.

💙🧡 Join us. Be part of the breakthrough. Donate today.💙🧡

The Association for Creatine Deficiencies (ACD) was established in 2012 by parents of children diagnosed with Cerebral Creatine Deficiency Syndrome (CCDS) who decided a rare disease needs a unified community to effect change for the future. The ACD Board consists of unpaid CCDS parent professionals committed to this cause.

A Cure for Gio