The Million Dollar Bike Ride

For the fourth year, the NR2F1 Foundation has an incredible team of 'athletes' riding in this year's Million Dollar Bike Ride on Saturday, June 13.

We are raising funds to support the NR2F1 Foundation, whose mission is to empower families living with rare NR2F1 gene variants (BBSOAS) through education, advocacy, and research.

Why This Matters

BBSOAS (Bosch-Boonstra-Schaaf Optic Atrophy Syndrome) is a rare, complex neurodevelopmental condition caused by variants in the NR2F1 gene. It affects vision, development, and often causes seizures or epilepsy.

Today, there are only ~500 diagnosed individuals worldwide — yet families urgently need answers, treatments, and hope.

Research is the only way forward.

What the NR2F1 Foundation Does

The NR2F1 Foundation is a global, patient-led nonprofit dedicated exclusively to families affected by rare NR2F1 gene variants.

Our vision is that every single family and individual living with rare NR2F1 variants will live a full and empowered life. Our mission is to empower families and individuals living with rare NR2F1 variants through education, advocacy and research.

Research the NR2F1 Foundation Funds — Around the World

The NR2F1 Foundation currently invests in BBSOAS research programs in Germany, France, and Italy, and in 2026 will open the first-ever dedicated BBSOAS research laboratory in the United States at Cincinnati Children’s Hospital Medical Center, led by Dr. Veeral Shah.

This U.S. lab — funded entirely by the Foundation — is a major milestone for families.

The 2026 Funding Goal: $320,000

Your donation helps fund:

NR2F1-exclusive post-doctoral researchers in Germany and Italy
The first dedicated BBSOAS research lab in the U.S.
The first-ever BBSOAS drug repurposing observational study
The 2026 BBSOAS Family & Scientific Conference

These projects move families closer to real treatments.

Help Lead the Way to Answers

For families living with BBSOAS, research means hope.

Your support fuels the science that will change lives.
Please donate today and help lead the way to answers.

NR2F1 Million Dollar Bike Ride 2026

Our Riders and Fundraisers

Team Members