The Foundation was the product of a partnership between the owners of Zikomo Safari (an Eco-Hotel ), who were concerned about the escalating loss of wildlife in the areas surrounding their lodge, and a passionate radio show host, who had a long history of defending and caring for animals.

Hotel owners, Victoria and David Wallace, and San Diego radio personality, Coe Lewis, had a collective vision of stopping the killing of African wildlife, while helping the Nsefu people rise above poverty. Coe became responsible for creating a visible U.S. presence, and the Wallace family became the Foundation's operational face in Zambia. Together they are the spine of the Nsefu Wildlife Conservation Foundation.

The Foundation shares a commitment to protecting and preserving African wildlife and ecosystems with many dedicated and effective organizations which have similar charters.

Guardian Gift Set