Behind every undiagnosed condition is a person, a family, a push for answers.

With your support, we’re not just imagining a future of diagnosis — we’re building it.

At the Undiagnosed Diseases Network Foundation (UDNF), we believe that no one should remain undiagnosed. That’s why we’re launching this campaign! Together, we can:

Connect patients to navigators and support
Advance research into rare and undiagnosed conditions
Push for faster, more accurate diagnoses
Grow a stronger, more connected community

But we can’t do it without you.

When you give to UDNF, you’re not just making a donation—you’re planting a seed of hope that grows into real, lasting change.

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The Undiagnosed Diseases Network Foundation (UDNF) is a patient-driven nonprofit fostering community, support, innovation, and action for families navigating the uncertainty of rare and undiagnosed conditions. Together, we can deliver on the hope for connection, answers, and improved outcomes.

For people facing a rare disease, the journey to a diagnosis is long, isolating, and costly. Families encounter more barriers than pathways and more questions than answers. Patients may see dozens of doctors and undergo countless tests before finally receiving a diagnosis. Even then, many rare and ultra-rare diseases have no known treatment. The impact is not rare, an estimated 25 million Americans are living with rare and undiagnosed conditions.

The UDNF is here to help. We provide a community of support where people can connect with others who truly understand their journey. We offer access to professional navigators, resources, and information, giving patients guidance through the complex healthcare system and beyond. We connect patients to research in rare disease diagnosis and treatment, driving progress toward more answers and cures. And we take action with the rare and undiagnosed community to improve experiences and outcomes.

At the core of the UDNF is a connection to the national Undiagnosed Diseases Network (UDN), a research network that aims to find answers for patients with mysterious and rare conditions.

Expand Our Roots - Help Grow the Future of Diagnosis

By Undiagnosed Diseases Network Foundation

Expand Our Roots - Help Grow the Future of Diagnosis

Support UDNF and families living without a diagnosis into 2026 and beyond

Team Members